Anti -EGFR Rabbit pAb

價格：在線咨詢

貨號：

KT012048

產品規(guī)格：

100ul

Applications：

Species：

H/M/R

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	EGFR rabbit polyclonal antibody
Protein full name	Epidermal growth factor receptor
Synonyms	EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse EGFR
Isotype	IgG
Purity	Affinity purification
Predicted MW.	134 kDa
Observed MW.	175 kDa
Uniprot ID	Q01279, P00533

Applications

Applications	Species	Dilution	Positive Sample
WB	Human, Mouse, Rat	1: 500-1: 1000	HepG2, A549, A431, Hacat, Hct116

Background

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.

Images

Picture 1.png

Western blot analysis of EGFR (GB11084-2) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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